human VAPB Over-expression AAV

Name 
AAV-h-VAPB
Cat No 
AAV-227394
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human VAPB.

AAV-227394
AAV-h-VAPB

Ready-to-use AAV expressing Human VAPB (VAMP associated protein B and C). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ALS8; VAMP (vesicle-associated membrane protein)-associated protein B and C; VAMP-associated 33 kDa protein; VAMP-associated protein B/C; VAMP-B; VAMP-B/VAMP-C; VAP-B; VAP-B/VAP-C; vesicle-associated membrane protein-associated protein B/C
Description (eCommerce)
Vesicle-associated membrane protein-associated protein B/C (VAPB) is a type IV membrane protein found in plasma and intracellular vesicle membranes and may play a role in vesicle trafficking. Defects in VAPB are the cause of amyotrophic lateral sclerosis type 8. ALS8 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Defects in VAPB are also a cause of spinal muscular atrophy autosomal dominant Finkel type (SMAF), also called late-onset spinal muscular atrophy Finkel type or spinal muscular atrophy proximal adult autosomal dominant [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O95292].
Description (Vector)
VAPB is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.
Gene ID
9217
Gene Name (eCommerce)
VAMP associated protein B and C
Gene Name (Vector)
VAMP associated protein B and C
Gene Symbol
VAPB
HGNC ID
HGNC:12649
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
732
Protein Name (eCommerce)
Vesicle-associated membrane protein-associated protein B/C
RefSeq ID
NM_004738
RefSeq Synonyms
NM_004738, NM_001195677, BC001712,
Research Areas
Amyotrophic Lateral Sclerosis (ALS),Apoptosis,Golgi Apparatus,Host-Virus Interactions,Metabolism/Metabolic Process,Neurobiology,Neurodegeneration,Protein Folding,Transport
Research Areas (Faceted)
neurobiology,cell_biology,infectious_disease,metabolism,neurobiology,cell_biology
Species
human
Target Sentence
Vesicle-associated membrane protein-associated protein B/C (VAPB) is a type IV membrane protein found in plasma and intracellular vesicle membranes and may play a role in vesicle trafficking. Defects in VAPB are the cause of amyotrophic lateral sclerosis type 8. ALS8 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Defects in VAPB are also a cause of spinal muscular atrophy autosomal dominant Finkel type (SMAF), also called late-onset spinal muscular atrophy Finkel type or spinal muscular atrophy proximal adult autosomal dominant [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O95292].
UniGene ID
Hs.182625
UniProt ID (eCommerce)
O95292

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.