human STX17 Over-expression AAV

Name 
AAV-h-STX17
Cat No 
AAV-224655
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human STX17.

AAV-224655
AAV-h-STX17

Ready-to-use AAV expressing Human STX17 (syntaxin 17). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
syntaxin-17
Description (eCommerce)
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P56962].
Gene ID
55014
Gene Name (eCommerce)
syntaxin 17
Gene Name (Vector)
syntaxin 17
Gene Symbol
STX17
HGNC ID
HGNC:11432
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
909
ORF Size (bp)
909 bp
Protein Name (eCommerce)
Syntaxin-17
RefSeq ID
NM_017919
RefSeq Synonyms
NM_017919, BC111009, BC101566, BC101564, BC051790,
Research Areas
Autophagy,Golgi Apparatus,Neurobiology
Research Areas (Faceted)
cell_biology,neurobiology
Species
human
Target Sentence
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P56962].
UniGene ID
Hs.709465
UniProt ID (eCommerce)
P56962

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.