human STK10 Over-expression AAV

Name 
AAV-h-STK10
Cat No 
AAV-224573
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human STK10.

AAV-224573
AAV-h-STK10

Ready-to-use AAV expressing Human STK10 (serine/threonine kinase 10). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
LOK; lymphocyte-oriented kinase; PRO2729; serine/threonine-protein kinase 10
Description (eCommerce)
LOK is a member of the Ste20 family of serine-threonine protein kinases. LOK associates with polo-like 1 kinase (PLK1) and may function to regulate its kinase activity. LOK has also been demonstrated to be involved in the regulation of the CD28 response-element in T-cells via the mitogen activated protein kinase kinase 1 pathway.
Description (Vector)
STK10 encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.
Gene ID
6793
Gene Name (eCommerce)
serine/threonine kinase 10
Gene Name (Vector)
serine/threonine kinase 10
Gene Symbol
STK10
HGNC ID
HGNC:11388
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2907
ORF Size (bp)
2907 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase 10
RefSeq ID
NM_005990
RefSeq Synonyms
NM_005990, BC070077, BC014413,
Research Areas
Cell Cycle,Immunology,Kinase/Phosphatase
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,immunology,signal_transduction
Species
human
Target Sentence
LOK is a member of the Ste20 family of serine-threonine protein kinases. LOK associates with polo-like 1 kinase (PLK1) and may function to regulate its kinase activity. LOK has also been demonstrated to be involved in the regulation of the CD28 response-element in T-cells via the mitogen activated protein kinase kinase 1 pathway.
UniGene ID
Hs.519756
UniProt ID (eCommerce)
O94804

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.