human STAT2 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-224537
Availability:
3-5 weeks
Name:
AAV-h-STAT2
This is an AAV expressing Human STAT2.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- STAT2
- Gene Name
- signal transducer and activator of transcription 2
- Gene ID
- 6773
- Gene Synonyms
- IMD44; ISGF-3; P113; STAT113
- ORF Size
- 2556 bp
- RefSeq#
- BC051284
- Gene Description
- STAT2 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.
- UniGene ID
- Hs.530595
- HGNC ID
- HGNC:11363
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