human SPRY4 Over-expression AAV

Name
AAV-h-SPRY4

Cat No
AAV-224275

Availability
4-5 weeks

This is an AAV expressing Human SPRY4.

AAV-224275

AAV-h-SPRY4

Ready-to-use AAV expressing Human SPRY4 (sprouty RTK signaling antagonist 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HH17

Description (Vector)

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002 (PubMed 12027893)).(supplied by OMIM, Mar 2008)

Gene ID

81848

Gene Name (Vector)

sprouty RTK signaling antagonist 4

Gene Symbol

SPRY4

HGNC ID

HGNC:15533

ORF Size (aa)

900

RefSeq ID

NM_030964

RefSeq Synonyms

NM_030964, NM_001293290, NM_001293289, NM_001127496, BC125096, BC125095,

Species

human

UniGene ID

Hs.323308

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.