human SPAG6 Over-expression AAV

Name 
AAV-h-SPAG6
Cat No 
AAV-224069
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SPAG6.

AAV-224069
AAV-h-SPAG6

Ready-to-use AAV expressing Human SPAG6 (sperm associated antigen 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CT141; pf16; Repro-SA-1
Description (Vector)
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene.
Gene ID
9576
Gene Name (Vector)
sperm associated antigen 6
Gene Symbol
SPAG6
HGNC ID
HGNC:11215
ORF Size (aa)
1377
ORF Size (bp)
1377 bp
RefSeq ID
NM_012443
RefSeq Synonyms
NM_172242, NM_012443, NM_001253855, NM_001253854, BC030585,
Species
human
UniGene ID
Hs.655170

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.