human SOD2 Over-expression AAV

Name
AAV-h-SOD2

Cat No
AAV-223981

Availability
4-5 weeks

This is an AAV expressing Human SOD2.

AAV-223981

AAV-h-SOD2

Ready-to-use AAV expressing Human SOD2 (superoxide dismutase 2, mitochondrial). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

epididymis secretory sperm binding protein; indophenoloxidase B; IPOB; IPO-B; manganese-containing superoxide dismutase; mangano-superoxide dismutase; Mn superoxide dismutase; MNSOD; Mn-SOD; MVCD6; superoxide dismutase Mn, mitochondrial; superoxide dismutase 2, mitochondrial

Description (eCommerce)

MnSOD (manganese superoxide dismutase) is a mitochondrial dismutase that catalyzes the conversion of superoxide byproducts of oxidative phosphorylation to hydrogen peroxide and diatomic oxygen.

Description (Vector)

SOD2 is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene ID

6648

Gene Name (eCommerce)

superoxide dismutase 2

Gene Name (Vector)

superoxide dismutase 2, mitochondrial

Gene Symbol

SOD2

HGNC ID

HGNC:11180

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

669

Protein Name (eCommerce)

Superoxide dismutase [Mn], mitochondrial

RefSeq ID

NM_000636

RefSeq Synonyms

NM_001322820, NM_001322819, NM_001322817, NM_001322816, NM_001322815, NM_001322814, NM_001024466, NM_001024465, NM_000636, BC016934, BC012423,

Research Areas

Aging,Apoptosis,Cardiac Development,Cardiology,Cardiovascular,DNA Damage/Repair,FoxO Signaling,Huntington's Disease,Hypoxia,IGF-1 Signaling,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,Neurodegeneration,Neurodevelopment,Signal Transduction,Transcription Factor/Regulator

Research Areas (Faceted)

signal_transduction,cell_biology,cardiovascular,genetics,transcription_translation,signal_transduction,neurobiology,cell_biology,metabolism,signal_transduction,cell_biology,neurobiology,developmental_biology,genetics,transcription_translation

Species

human

Target Sentence

MnSOD (manganese superoxide dismutase) is a mitochondrial dismutase that catalyzes the conversion of superoxide byproducts of oxidative phosphorylation to hydrogen peroxide and diatomic oxygen.

UniGene ID

Hs.487046

UniProt ID (eCommerce)

P04179

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.