human SNW1 Over-expression AAV

Name 
AAV-h-SNW1
Cat No 
AAV-223910
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SNW1.

AAV-223910
AAV-h-SNW1

Ready-to-use AAV expressing Human SNW1 (SNW domain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Bx42; FUN20; homolog of Drosophila BX42; NCOA-62; nuclear protein SkiP; nuclear receptor coactivator NCoA-62; nuclear receptor coactivator, 62-kD; Prp45; PRPF45; SKI interacting protein; ski-interacting protein; SKIIP; SKIP; SKIP1; SNW domain-containing protein 1
Description (eCommerce)
NCOA62 is an integral component of the splicesome that functions in pre-mRNA splicing. NCOA62 has also been demonstrated to function as a coactivator of the Notch transcription factor and the vitamin D nuclear receptor. Additionally, NCOA2 exhibits transcriptional repression activity and associates with the N-Cor and SMRT corepressors. Recent evidence suggests a role for NCOA62 in transcription elongation.
Description (Vector)
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.
Gene ID
22938
Gene Name (eCommerce)
SNW domain containing 1
Gene Name (Vector)
SNW domain containing 1
Gene Symbol
SNW1
HGNC ID
HGNC:16696
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1611
ORF Size (bp)
1611 bp
Protein Name (eCommerce)
SNW domain-containing protein 1
RefSeq ID
NM_012245
RefSeq Synonyms
NM_012245, NM_001318844, BC108903,
Research Areas
Cancer,Gene Expression,Host-Virus Interactions,mRNA Processing,mRNA Splicing,Neurobiology,Neurodevelopment,Neurogenesis,Notch Signaling,Nuclear Receptor Coactivators,RNA Processing,Signal Transduction,Spliceosome,TGF-beta Signaling,Transcription Factor/Regulator,Viral Carcinogenesis
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,genetics,transcription_translation,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
NCOA62 is an integral component of the splicesome that functions in pre-mRNA splicing. NCOA62 has also been demonstrated to function as a coactivator of the Notch transcription factor and the vitamin D nuclear receptor. Additionally, NCOA2 exhibits transcriptional repression activity and associates with the N-Cor and SMRT corepressors. Recent evidence suggests a role for NCOA62 in transcription elongation.
UniGene ID
Hs.445498
UniProt ID (eCommerce)
Q13573

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.