human SMPD1 Over-expression AAV

Name 
AAV-h-SMPD1
Cat No 
AAV-223767
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SMPD1.

AAV-223767
AAV-h-SMPD1

Ready-to-use AAV expressing Human SMPD1 (sphingomyelin phosphodiesterase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ASM; ASMASE; NPD
Description (Vector)
SMPD1 is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified.
Gene ID
6609
Gene Name (Vector)
sphingomyelin phosphodiesterase 1
Gene Symbol
SMPD1
HGNC ID
HGNC:11120
ORF Size (aa)
1095
RefSeq ID
NM_000543
RefSeq Synonyms
NM_001318088, NM_001318087, NM_001007593, NM_000543, BC041164,
Species
human
UniGene ID
Hs.498173

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.