human SIRT1 Over-expression AAV

Name 
AAV-h-SIRT1
Cat No 
AAV-223014
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SIRT1.

AAV-223014
AAV-h-SIRT1

Ready-to-use AAV expressing Human SIRT1 (sirtuin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
hSIR2; hSIRT1; NAD-dependent protein deacetylase sirtuin-1; regulatory protein SIR2 homolog 1; SIR2; SIR2alpha; SIR2L1; SIR2-like protein 1; sirtuin type 1
Description (eCommerce)
Sirt1 is one of seven members of the sirtuin family of proteins that are homologous to the yeast silent information regulator 2 (Sir2), a NAD+-dependent protein deacetylase that plays a role in lifespan in lower eukaryotes. The sirtuins are diverse in their cellular functions, and are important to the regulation of oxidative stress, and metabolism. Sirt 1 is localized to the nucleus and possesses deacetylase activity. Sirt 1 has been shown to be able to deacetylate p53, Ku70, NF-kappaB and forkhead proteins to mediate cellular resistance to stress.
Gene ID
23411
Gene Name (eCommerce)
sirtuin 1
Gene Name (Vector)
sirtuin 1
Gene Symbol
SIRT1
HGNC ID
HGNC:14929
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1668
ORF Size (bp)
1668 bp
Protein Name (eCommerce)
NAD-dependent protein deacetylase sirtuin-1
RefSeq ID
NM_012238
RefSeq Synonyms
NM_012238, NM_001314049, NM_001142498, BC012499,
Research Areas
Aging,Angiogenesis,Apoptosis,Autophagy,Breast Cancer,Cancer,Cell Cycle,Chromatin Remodeling,DNA Damage/Repair,DNA Replication,Epigenetic Regulation of Gene Expression,FoxO Signaling,Helicase Activity,Histone Modification,Host-Virus Interactions,Hypoxia,Immunology,Insulin Signaling,Metabolism/Metabolic Process,MicroRNAs in Cancer,Mitochondrion,NF-kB Signaling,RNA Processing,Signal Transduction,Spermatogenesis,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,immunology,infectious_disease,metabolism,signal_transduction
Species
human
Target Sentence
Sirt1 is one of seven members of the sirtuin family of proteins that are homologous to the yeast silent information regulator 2 (Sir2), a NAD+-dependent protein deacetylase that plays a role in lifespan in lower eukaryotes. The sirtuins are diverse in their cellular functions, and are important to the regulation of oxidative stress, and metabolism. Sirt 1 is localized to the nucleus and possesses deacetylase activity. Sirt 1 has been shown to be able to deacetylate p53, Ku70, NF-kappaB and forkhead proteins to mediate cellular resistance to stress.
UniGene ID
Hs.369779
UniProt ID (eCommerce)
Q96EB6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.