human SESN1 Over-expression AAV

Name 
AAV-h-SESN1
Cat No 
AAV-222724
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SESN1.

AAV-222724
AAV-h-SESN1

Ready-to-use AAV expressing Human SESN1 (sestrin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
PA26; SEST1
Description (Vector)
SESN1 encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
27244
Gene Name (Vector)
sestrin 1
Gene Symbol
SESN1
HGNC ID
HGNC:21595
ORF Size (aa)
1656
ORF Size (bp)
1656 bp
RefSeq ID
NM_014454
RefSeq Synonyms
NM_014454, NM_001199934, NM_001199933, BC113569, BC112036,
Species
human
UniGene ID
Hs.591336

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.