human RUNX1T1 Over-expression AAV

Name 
AAV-h-RUNX1T1
Cat No 
AAV-222115
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human RUNX1T1.

AAV-222115
AAV-h-RUNX1T1

Ready-to-use AAV expressing Human RUNX1T1 (RUNX1 translocation partner 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
acute myelogenous leukemia 1 translocation 1, cyclin-D related; AML1-MTG8; AML1T1; CBFA2T1; CDR; core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related; Cyclin-D-related protein; eight twenty one protein; ETO; MTG8; myeloid translocation gene on 8q22; protein CBFA2T1; Protein ETO; Protein MTG8; runt related transcription factor 1; translocated to, 1 (cyclin D related); zinc finger MYND domain-containing protein 2; ZMYND2
Description (eCommerce)
ETO (eight twenty-one protein) is also known as MTG8 (myeloid translocation gene on 8q22) and was identified as part of an 8:21 chromosomal breakpoint in leukemia cells. ETO is encoded by the RUNX1T1 (runt-related transcription factor; translocated to, 1 (cyclin D-related) gene and functions as a transcriptional co-repressor.
Description (Vector)
RUNX1T1 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.
Gene ID
862
Gene Name (eCommerce)
RUNX1 translocation partner 1
Gene Name (Vector)
RUNX1 translocation partner 1
Gene Symbol
RUNX1T1
HGNC ID
HGNC:1535
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1704
ORF Size (bp)
1704 bp
Protein Name (eCommerce)
Protein CBFA2T1
RefSeq ID
NM_004349
RefSeq Synonyms
NM_175636, NM_175635, NM_175634, NM_004349, NM_001198679, NM_001198634, NM_001198633, NM_001198632, NM_001198631, NM_001198630, NM_001198629, NM_001198628, NM_001198627, NM_001198626, NM_001198625, BC067078, BC005850,
Research Areas
Cancer,Leukemia,Metabolism/Metabolic Process,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,metabolism,transcription_translation
Species
human
Target Sentence
ETO (eight twenty-one protein) is also known as MTG8 (myeloid translocation gene on 8q22) and was identified as part of an 8:21 chromosomal breakpoint in leukemia cells. ETO is encoded by the RUNX1T1 (runt-related transcription factor; translocated to, 1 (cyclin D-related) gene and functions as a transcriptional co-repressor.
UniGene ID
Hs.368431
UniProt ID (eCommerce)
Q06455

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.