human RRAGC Over-expression AAV

Name 
AAV-h-RRAGC
Cat No 
AAV-221991
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human RRAGC.

AAV-221991
AAV-h-RRAGC

Ready-to-use AAV expressing Human RRAGC (Ras related GTP binding C). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
GTPase-interacting protein 2; GTR2; Rag C; Rag C protein; RAGC; ras-related GTP-binding protein C; TIB929
Description (eCommerce)
Ras-related GTP-binding protein C (RagC) has guanine nucleotide-binding activity but weak intrinsic GTPase activity. RagC is probably required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9HB90].
Description (Vector)
RRAGC is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.(supplied by OMIM, Apr 2004)
Gene ID
64121
Gene Name (eCommerce)
Ras related GTP binding C
Gene Name (Vector)
Ras related GTP binding C
Gene Symbol
RRAGC
HGNC ID
HGNC:19902
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1200
ORF Size (bp)
1200 bp
Protein Name (eCommerce)
Ras-related GTP-binding protein C
RefSeq ID
NM_022157
RefSeq Synonyms
NM_022157, NM_001271851, BC016668,
Research Areas
Apoptosis,Lysosome,mTOR Signaling,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,signal_transduction,transcription_translation
Species
human
Target Sentence
Ras-related GTP-binding protein C (RagC) has guanine nucleotide-binding activity but weak intrinsic GTPase activity. RagC is probably required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9HB90].
UniGene ID
Hs.532461
UniProt ID (eCommerce)
Q9HB90

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.