human RGS14 Over-expression AAV

Name 
AAV-h-RGS14
Cat No 
AAV-221114
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human RGS14.

AAV-221114
AAV-h-RGS14

Ready-to-use AAV expressing Human RGS14 (regulator of G-protein signaling 14). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
regulator of G-protein signaling 14; regulator of G-protein signalling 14; RGS14
Description (eCommerce)
Regulator of G-protein signaling 14 (RGS14) acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). RGS14 may act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43566].
Description (Vector)
RGS14 encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Gene ID
10636
Gene Name (eCommerce)
regulator of G protein signaling 14
Gene Name (Vector)
regulator of G-protein signaling 14
Gene Symbol
RGS14
HGNC ID
HGNC:9996
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1701
ORF Size (bp)
1701 bp
Protein Name (eCommerce)
Regulator of G-protein signaling 14
RefSeq ID
NM_006480
RefSeq Synonyms
NM_006480, BC014094,
Research Areas
Cardiology,Cardiovascular,Cell Cycle,Cell Division,Cytoskeleton,GPCR Signaling,Neurobiology,Neurodevelopment,Neurogenesis,Signal Transduction,Synapse
Research Areas (Faceted)
cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,neurobiology,signal_transduction
Species
human
Target Sentence
Regulator of G-protein signaling 14 (RGS14) acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). RGS14 may act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43566].
UniGene ID
Hs.9347
UniProt ID (eCommerce)
O43566

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.