human RB1 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-220819
Availability:
3-5 weeks
Name:
AAV-h-RB1
This is an AAV expressing Human RB1.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- RB1
- Gene Name
- RB transcriptional corepressor 1
- Gene ID
- 5925
- Gene Synonyms
- OSRC; p105-Rb; pp110; PPP1R130; pRb; RB
- ORF Size
- 2787 bp
- RefSeq#
- BC039060
- Gene Description
- RB1 is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
- UniGene ID
- Hs.408528
- HGNC ID
- HGNC:9884
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