human PXK Over-expression AAV

Name 
AAV-h-PXK
Cat No 
AAV-220428
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PXK.

AAV-220428
AAV-h-PXK

Ready-to-use AAV expressing Human PXK (PX domain containing serine/threonine kinase like). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Modulator of Na,K-ATPase; modulator of Na,K-ATPase long form; MONAKA; PX domain-containing protein kinase-like protein; PX ser/thr kinase v2; PX serine/threonine kinase; SLOB
Description (eCommerce)
PX domain-containing protein kinase-like protein (PXK) binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission.PXK may not display kinase activity [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q7Z7A4].
Description (Vector)
PXK binds to the Na,K-ATPase beta-1 (ATP1B1; MIM 182330) and beta-3 (ATP1B3; MIM 601867) subunits and modulates both Na,K-ATPase enzymatic and ion pump activities (Mao et al., 2005 (PubMed 16135750)).(supplied by OMIM, Mar 2008)
Gene ID
54899
Gene Name (eCommerce)
PX domain containing serine/threonine kinase like
Gene Name (Vector)
PX domain containing serine/threonine kinase like
Gene Symbol
PXK
HGNC ID
HGNC:23326
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1353
ORF Size (bp)
1353 bp
Protein Name (eCommerce)
PX domain-containing protein kinase-like protein
RefSeq ID
NM_017771
RefSeq Synonyms
NM_017771, NM_001289101, NM_001289100, NM_001289099, NM_001289098, NM_001289096, NM_001289095, BC014479,
Research Areas
Immunology,Kinase/Phosphatase,Neurobiology
Research Areas (Faceted)
cell_biology,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
PX domain-containing protein kinase-like protein (PXK) binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission.PXK may not display kinase activity [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q7Z7A4].
UniGene ID
Hs.190544
UniProt ID (eCommerce)
Q7Z7A4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.