human PXK shRNA silencing Adenovirus

Name 
Ad-h-PXK-shRNA
Cat No 
shADV-220428
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PXK.

shADV-220428
Ad-h-PXK-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PXK (PX domain containing serine/threonine kinase like). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Modulator of Na,K-ATPase; modulator of Na,K-ATPase long form; MONAKA; PX domain-containing protein kinase-like protein; PX ser/thr kinase v2; PX serine/threonine kinase; SLOB
Description (eCommerce)
PX domain-containing protein kinase-like protein (PXK) binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission.PXK may not display kinase activity [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q7Z7A4].
Description (Vector)
PXK binds to the Na,K-ATPase beta-1 (ATP1B1; MIM 182330) and beta-3 (ATP1B3; MIM 601867) subunits and modulates both Na,K-ATPase enzymatic and ion pump activities (Mao et al., 2005 (PubMed 16135750)).(supplied by OMIM, Mar 2008)
Gene ID
54899
Gene Name (eCommerce)
PX domain containing serine/threonine kinase like
Gene Name (Vector)
PX domain containing serine/threonine kinase like
Gene Symbol
PXK
HGNC ID
HGNC:23326
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1353
ORF Size (bp)
1353 bp
Protein Name (eCommerce)
PX domain-containing protein kinase-like protein
RefSeq ID
NM_017771
RefSeq Synonyms
NM_017771, NM_001289101, NM_001289100, NM_001289099, NM_001289098, NM_001289096, NM_001289095, BC014479,
Research Areas
Immunology,Kinase/Phosphatase,Neurobiology
Research Areas (Faceted)
cell_biology,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
PX domain-containing protein kinase-like protein (PXK) binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission.PXK may not display kinase activity [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q7Z7A4].
UniGene ID
Hs.190544
UniProt ID (eCommerce)
Q7Z7A4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.