human PQBP1 Over-expression AAV

Name 
AAV-h-PQBP1
Cat No 
AAV-219702
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PQBP1.

AAV-219702
AAV-h-PQBP1

Ready-to-use AAV expressing Human PQBP1 (polyglutamine binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
38 kDa nuclear protein containing a WW domain; MRX2; MRX55; MRXS3; MRXS8; NPW38; polyglutamine tract-binding protein 1; polyglutamine-binding protein 1; PQBP-1; RENS1; SHS
Description (eCommerce)
Polyglutamine-binding protein 1 (PQBP1) is a nuclear polyglutamine-binding protein that is involved with transcriptional activation. Mutations in the PQBP1 gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked mental retardation [taken from NCBI Entrez Gene (Gene ID: 10084].
Description (Vector)
PQBP1 encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. The encoded protein contains a WW domain. Mutations in this gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked mental retardation. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Gene ID
10084
Gene Name (eCommerce)
polyglutamine binding protein 1
Gene Name (Vector)
polyglutamine binding protein 1
Gene Symbol
PQBP1
HGNC ID
HGNC:9330
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
798
Protein Name (eCommerce)
Polyglutamine-binding protein 1
RefSeq ID
NM_005710
RefSeq Synonyms
NM_144495, NM_005710, NM_001167992, NM_001167990, NM_001167989, NM_001032384, NM_001032383, NM_001032382, NM_001032381, BC012358,
Research Areas
Gene Expression,Neurobiology,RNA Processing,Spliceosome,Transcription Factor/Regulator
Research Areas (Faceted)
genetics,transcription_translation,neurobiology,cell_biology
Species
human
Target Sentence
Polyglutamine-binding protein 1 (PQBP1) is a nuclear polyglutamine-binding protein that is involved with transcriptional activation. Mutations in the PQBP1 gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked mental retardation [taken from NCBI Entrez Gene (Gene ID: 10084].
UniGene ID
Hs.534384
UniProt ID (eCommerce)
O60828

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.