human PPARGC1A Over-expression AAV
This is an AAV expressing Human PPARGC1A.
AAV-219512
AAV-h-PPARGC1A
Ready-to-use AAV expressing Human PPARGC1A (PPARG coactivator 1 alpha). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
LEM6; Ligand effect modulator 6; ligand effect modulator-6; L-PGC-1alpha; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC1; PGC-1(alpha); PGC1A; PGC-1alpha; PGC-1-alpha; PGC-1v; PPAR gamma coactivator variant form; PPARgamma coactivator 1alpha; PPAR-gamma coactivator 1-alpha; PPARGC1; PPARGC-1-alpha
Description (eCommerce)
PGC-1 (PPARgamma coactivator 1) is a nuclear receptor co-activator involved in energy metabolism. PGC-1 was identified as a factor that interacted with the nuclear receptor, PPARgamma. PGC-1 functions as a docking platform for complexes involved in transcriptional regulation such as histone acetyltransferase (HAT) complexes and the TRAP/DRIP (Mediator) complex.
Description (Vector)
PPARGC1A is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
Gene ID
10891
Gene Name (eCommerce)
PPARG coactivator 1 alpha
Gene Name (Vector)
PPARG coactivator 1 alpha
Gene Symbol
PPARGC1A
HGNC ID
HGNC:9237
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2397
ORF Size (bp)
2397 bp
Protein Name (eCommerce)
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
RefSeq ID
NM_013261
RefSeq Synonyms
NM_013261, NM_001330753, NM_001330752, NM_001330751, BC157068, BC156323,
Research Areas
Apoptosis,Histone Modification,Huntington's Disease,Insulin Signaling,Metabolism/Metabolic Process,mRNA Processing,mTOR Signaling,Neurobiology,Neurodegeneration,Neurodevelopment,Nuclear Receptor Coactivators,RNA Binding,RNA Processing,Signal Transduction,Transcription Factor/Regulator,Transport
Research Areas (Faceted)
cell_biology,developmental_biology,genetics,transcription_translation,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
PGC-1 (PPARgamma coactivator 1) is a nuclear receptor co-activator involved in energy metabolism. PGC-1 was identified as a factor that interacted with the nuclear receptor, PPARgamma. PGC-1 functions as a docking platform for complexes involved in transcriptional regulation such as histone acetyltransferase (HAT) complexes and the TRAP/DRIP (Mediator) complex.
UniGene ID
Hs.527078
UniProt ID (eCommerce)
Q9UBK2
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.