human PIGA Over-expression AAV

Name
AAV-h-PIGA

Cat No
AAV-218902

Availability
4-5 weeks

This is an AAV expressing Human PIGA.

AAV-218902

AAV-h-PIGA

Ready-to-use AAV expressing Human PIGA (phosphatidylinositol glycan anchor biosynthesis class A). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GPI3; MCAHS2; PIG-A; PNH1

Description (Vector)

PIGA encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12.

Gene ID

5277

Gene Name (Vector)

phosphatidylinositol glycan anchor biosynthesis class A

Gene Symbol

PIGA

HGNC ID

HGNC:8957

ORF Size (aa)

1455

ORF Size (bp)

1455 bp

RefSeq ID

NM_002641

RefSeq Synonyms

NM_020473, NM_002641, BC038236,

Species

human

UniGene ID

Hs.137154

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.