human PIGA shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PIGA.
shAAV-218902
AAV-h-PIGA-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PIGA (phosphatidylinositol glycan anchor biosynthesis class A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GPI3; MCAHS2; PIG-A; PNH1
Description (Vector)
PIGA encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12.
Gene ID
5277
Gene Name (Vector)
phosphatidylinositol glycan anchor biosynthesis class A
Gene Symbol
PIGA
HGNC ID
HGNC:8957
ORF Size (aa)
1455
ORF Size (bp)
1455 bp
RefSeq ID
NM_002641
RefSeq Synonyms
NM_020473, NM_002641, BC038236,
Species
human
UniGene ID
Hs.137154
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.