human PFKFB1 Over-expression AAV

Name
AAV-h-PFKFB1

Cat No
AAV-218666

Availability
4-5 weeks

This is an AAV expressing Human PFKFB1.

AAV-218666

AAV-h-PFKFB1

Ready-to-use AAV expressing Human PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

F6PK; HL2K; PFRX

Description (Vector)

PFKFB1 encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.

Gene ID

5207

Gene Name (Vector)

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Gene Symbol

PFKFB1

HGNC ID

HGNC:8872

ORF Size (aa)

816

RefSeq ID

NM_002625

RefSeq Synonyms

NM_002625, NM_001271805, NM_001271804, BC096079, BC096078, BC096077,

Species

human

UniGene ID

Hs.444304

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.