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human PFKFB1 shRNA silencing AAV

Name 
AAV-h-PFKFB1-shRNA
Cat No 
shAAV-218667
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PFKFB1.

shAAV-218667
AAV-h-PFKFB1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
F6PK; HL2K; PFRX
Description (Vector)
PFKFB1 encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.
Gene ID
5207
Gene Name (Vector)
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Gene Symbol
PFKFB1
HGNC ID
HGNC:8872
ORF Size (aa)
816
RefSeq ID
NM_002625
RefSeq Synonyms
NM_002625, NM_001271805, NM_001271804, BC096079, BC096078, BC096077,
Species
human
UniGene ID
Hs.444304

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.