human PAM Over-expression AAV

Name 
AAV-h-PAM
Cat No 
AAV-218168
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PAM.

AAV-218168
AAV-h-PAM

Ready-to-use AAV expressing Human PAM (peptidylglycine alpha-amidating monooxygenase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
PAL; PHM
Description (Vector)
PAM encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known.
Gene ID
5066
Gene Name (Vector)
peptidylglycine alpha-amidating monooxygenase
Gene Symbol
PAM
HGNC ID
HGNC:8596
ORF Size (aa)
2601
ORF Size (bp)
2601 bp
RefSeq ID
NM_000919
RefSeq Synonyms
NM_138822, NM_138821, NM_138766, NM_001319943, NM_001177306, NM_000919, BC018127,
Species
human
UniGene ID
Hs.369430

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.