human PAK3 Over-expression AAV

Name
AAV-h-PAK3

Cat No
AAV-218154

Availability
4-5 weeks

This is an AAV expressing Human PAK3.

AAV-218154

AAV-h-PAK3

Ready-to-use AAV expressing Human PAK3 (p21 (RAC1) activated kinase 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ARA; beta-PAK; bPAK; MRX30; MRX47; OPHN3; PAK-3; PAK3beta

Description (Vector)

PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene ID

5063

Gene Name (Vector)

p21 (RAC1) activated kinase 3

Gene Symbol

PAK3

HGNC ID

HGNC:8592

ORF Size (aa)

1632

ORF Size (bp)

1632 bp

RefSeq ID

NM_002578

RefSeq Synonyms

NM_002578, NM_001324334, NM_001324333, NM_001324332, NM_001324331, NM_001324330, NM_001324329, NM_001324328, NM_001324327, NM_001324326, NM_001324325, NM_001128173, NM_001128172, NM_001128168, NM_001128167, NM_001128166, BC152761,

Species

human

UniGene ID

Hs.656789

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.