human PACRG Over-expression AAV

Name 
AAV-h-PACRG
Cat No 
AAV-218101
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PACRG.

AAV-218101
AAV-h-PACRG

Ready-to-use AAV expressing Human PACRG (PARK2 coregulated). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
GLUP; HAK005771; PARK2CRG
Description (Vector)
PACRG encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
135138
Gene Name (Vector)
PARK2 coregulated
Gene Symbol
PACRG
HGNC ID
HGNC:19152
ORF Size (aa)
774
RefSeq ID
NM_152410
RefSeq Synonyms
NM_152410, NM_001080379, NM_001080378, BC044227, BC030642,
Species
human
UniGene ID
Hs.25791

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.