human NMNAT1 Over-expression AAV

Name 
AAV-h-NMNAT1
Cat No 
AAV-216828
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human NMNAT1.

AAV-216828
AAV-h-NMNAT1

Ready-to-use AAV expressing Human NMNAT1 (nicotinamide nucleotide adenylyltransferase 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
LCA9; NaMN adenylyltransferase 1; nicotinamide mononucleotide adenylyltransferase 1; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; Nicotinamide-nucleotide adenylyltransferase 1; nicotinate-nucleotide adenylyltransferase 1; NMN adenylyltransferase 1; NMN/NaMN adenylyltransferase 1; NMNAT; PNAT1; pyridine nucleotide adenylyltransferase 1
Description (eCommerce)
Nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1) catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. NMNAT1 is an enzyme which catalyzes a key step in the biosynthesis of the coenzyme NAD. NMNAT1 is one of several nicotinamide nucleotide adenylyltransferases. Studies in Drosophila and mammalian neurons have shown NMNAT1 can confer protection to damaged neurons. This protection requires enzymatic activity which increases NAD levels and activates a nuclear deacetylase which is the protective molecul [taken from NCBI Entrez Gene (Gene ID: 64802)].
Description (Vector)
NMNAT1 encodes an enzyme which catalyzes a key step in the biosynthesis of the coenzyme NAD. The encoded protein is one of several nicotinamide nucleotide adenylyltransferases. Studies in Drosophila and mammalian neurons have shown the encoded protein can confer protection to damaged neurons. This protection requires enzymatic activity which increases NAD levels and activates a nuclear deacetylase which is the protective molecule. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14 and 15.
Gene ID
64802
Gene Name (eCommerce)
nicotinamide nucleotide adenylyltransferase 1
Gene Name (Vector)
nicotinamide nucleotide adenylyltransferase 1
Gene Symbol
NMNAT1
HGNC ID
HGNC:17877
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
840
Protein Name (eCommerce)
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
RefSeq ID
NM_022787
RefSeq Synonyms
NM_022787, NM_001297779, NM_001297778, BC014943,
Research Areas
Metabolism/Metabolic Process
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
Nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1) catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. NMNAT1 is an enzyme which catalyzes a key step in the biosynthesis of the coenzyme NAD. NMNAT1 is one of several nicotinamide nucleotide adenylyltransferases. Studies in Drosophila and mammalian neurons have shown NMNAT1 can confer protection to damaged neurons. This protection requires enzymatic activity which increases NAD levels and activates a nuclear deacetylase which is the protective molecul [taken from NCBI Entrez Gene (Gene ID: 64802)].
UniGene ID
Hs.633762
UniProt ID (eCommerce)
Q9HAN9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.