human NEDD4 Over-expression AAV

Name 
AAV-h-NEDD4
Cat No 
AAV-216548
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human NEDD4.

AAV-216548
AAV-h-NEDD4

Ready-to-use AAV expressing Human NEDD4 (neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
cell proliferation-inducing gene 53 protein; E3 ubiquitin-protein ligase NEDD4; HECT-type E3 ubiquitin transferase NEDD4; NEDD-4; NEDD4-1; Neural precursor cell expressed developmentally down-regulated protein 4; receptor-potentiating factor 1; RPF1
Description (eCommerce)
NEDD4 (neural precursor cell expressed developmentally down-regulated protein 4) is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Independent of its ubiquitin-ligase activity, NEDD4 is involved in the pathway leading to the degradation of VEGFR-2/KDFR [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P46934].
Gene ID
4734
Gene Name (eCommerce)
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Gene Name (Vector)
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Gene Symbol
NEDD4
HGNC ID
HGNC:7727
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3912
ORF Size (bp)
3912 bp
Protein Name (eCommerce)
E3 ubiquitin-protein ligase NEDD4
RefSeq ID
NM_006154
RefSeq Synonyms
NM_198400, NM_006154, NM_001329212, NM_001284340, NM_001284339, NM_001284338, BC152562, BC152452, BC144285, BC144284, BC136605,
Research Areas
Antigen Processing and Presentation,Cardiovascular,Complexome,Cytokine Signaling,EGFR Signaling,Golgi Apparatus,Host-Virus Interactions,IFN Signaling,Immunology,Lysosomal Transport,Neurobiology,Neurodevelopment,Neurogenesis,Proteasome,RNA Binding,Signal Transduction,Transport,Ubiquitination,VEGF Signaling
Research Areas (Faceted)
cardiovascular,cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
NEDD4 (neural precursor cell expressed developmentally down-regulated protein 4) is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Independent of its ubiquitin-ligase activity, NEDD4 is involved in the pathway leading to the degradation of VEGFR-2/KDFR [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P46934].
UniGene ID
Hs.1565
UniProt ID (eCommerce)
P46934

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.