human NDE1 Over-expression AAV

Name 
AAV-h-NDE1
Cat No 
AAV-216443
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human NDE1.

AAV-216443
AAV-h-NDE1

Ready-to-use AAV expressing Human NDE1 (nudE neurodevelopment protein 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
epididymis secretory sperm binding protein; HOM-TES-87; LIS1-interacting protein NUDE1, rat homolog; LIS4; MHAC; NDE; nuclear distribution protein nudE homolog 1; NUDE; nudE nuclear distribution E homolog 1; nudE nuclear distribution gene E homolog 1; NUDE1
Description (eCommerce)
NDE1 (nuclear distribution factor E homolog 1) is important to microtubule organization, mitosis, and cell migration. It is required for the duplication of centrosomes and the function of the mitotic spindle. NDE1 is a binding partner of DISC1 (disrupted-in-schizophrenia 1) along with LIS1 (lissencephaly 1) at the centrosome and at synapses in neurons. It is also part of a multiprotein complex that regulates dynein. The NDE1 gene has been identified as a schizophrenia-associated locus.
Description (Vector)
NDE1 encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants.
Gene ID
54820
Gene Name (eCommerce)
nudE neurodevelopment protein 1
Gene Name (Vector)
nudE neurodevelopment protein 1
Gene Symbol
NDE1
HGNC ID
HGNC:17619
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1008
ORF Size (bp)
1008 bp
Protein Name (eCommerce)
Nuclear distribution protein nudE homolog 1
RefSeq ID
NM_017668
RefSeq Synonyms
NM_017668, NM_001143979, BC033900, BC001421,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton,Neurobiology,Neurodevelopment,Neurogenesis
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,neurobiology
Species
human
Target Sentence
NDE1 (nuclear distribution factor E homolog 1) is important to microtubule organization, mitosis, and cell migration. It is required for the duplication of centrosomes and the function of the mitotic spindle. NDE1 is a binding partner of DISC1 (disrupted-in-schizophrenia 1) along with LIS1 (lissencephaly 1) at the centrosome and at synapses in neurons. It is also part of a multiprotein complex that regulates dynein. The NDE1 gene has been identified as a schizophrenia-associated locus.
UniGene ID
Hs.655378
UniProt ID (eCommerce)
Q9NXR1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.