human MYCN Over-expression AAV

Name 
AAV-h-MYCN
Cat No 
AAV-216142
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human MYCN.

AAV-216142
AAV-h-MYCN

Ready-to-use AAV expressing Human MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
bHLHe37;class E basic helix-loop-helix protein 37;MODED;neuroblastoma MYC oncogene;neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene;NMYC;N-myc;N-myc proto-oncogene protein;ODED;oncogene NMYC;v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
Description (eCommerce)
N-Myc is a member of the Myc family of proteins which include c-Myc, N-Myc, and L-Myc. Myc family members are transactivating DNA binding proteins with oncogenic potential. Transactivation by Myc requires dimerization with other basic helix-loop-helix transcription factors. N-myc dimerizes with the MAX transcription factor.
Description (Vector)
MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.
Gene ID
4613
Gene Name (eCommerce)
MYCN proto-oncogene, bHLH transcription factor
Gene Name (Vector)
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
Gene Symbol
MYCN
HGNC ID
HGNC:7559
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1395
ORF Size (bp)
1395 bp
Protein Name (eCommerce)
N-myc proto-oncogene protein
RefSeq ID
NM_005378
RefSeq Synonyms
NM_005378, NM_001293233, NM_001293231, NM_001293228, BC002712,
Research Areas (Faceted)
cell_biology,immunology,transcription_translation,cancer
Species
human
UniGene ID
Hs.25960
UniProt ID (eCommerce)
P04198

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.