human MSLN Over-expression AAV

Name
AAV-h-MSLN

Cat No
AAV-215924

Availability
4-5 weeks

Categories
AAV, Over-Expression

This is an AAV expressing Human MSLN.

AAV-215924

AAV-h-MSLN

Ready-to-use AAV expressing Human MSLN (mesothelin). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MPF; SMRP

Description (Vector)

MSLN encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.

Gene ID

10232

Gene Name (Vector)

mesothelin

Gene Symbol

MSLN

HGNC ID

HGNC:7371

ORF Size (aa)

1866

ORF Size (bp)

1866 bp

RefSeq ID

NM_013404

RefSeq Synonyms

NM_013404, NM_005823, NM_001177355, BC009272, BC003512,

Species

human

UniGene ID

Hs.408488

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.