human MFNG Over-expression AAV

Name
AAV-h-MFNG

Cat No
AAV-215369

Availability
4-5 weeks

This is an AAV expressing Human MFNG.

AAV-215369

AAV-h-MFNG

Ready-to-use AAV expressing Human MFNG (MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

MFNG is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling.

Gene ID

4242

Gene Name (Vector)

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Gene Symbol

MFNG

HGNC ID

HGNC:7038

ORF Size (aa)

966

ORF Size (bp)

966 bp

RefSeq ID

NM_002405

RefSeq Synonyms

NM_002405, NM_001166343, BC094814,

Species

human

UniGene ID

Hs.517603

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.