human MEGF10 Over-expression AAV

Name
AAV-h-MEGF10

Cat No
AAV-215278

Availability
4-5 weeks

This is an AAV expressing Human MEGF10.

AAV-215278

AAV-h-MEGF10

Ready-to-use AAV expressing Human MEGF10 (multiple EGF like domains 10). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

EMARDD

Description (Vector)

MEGF10 encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene.

Gene ID

84466

Gene Name (Vector)

multiple EGF like domains 10

Gene Symbol

MEGF10

HGNC ID

HGNC:29634

ORF Size (aa)

3423

ORF Size (bp)

3423 bp

RefSeq ID

NM_032446

RefSeq Synonyms

NM_032446, NM_001308121, NM_001308119, NM_001256545, BC152478,

Species

human

UniGene ID

Hs.438709

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.