human MAP3K12 Over-expression AAV

Name 
AAV-h-MAP3K12
Cat No 
AAV-214926
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human MAP3K12.

AAV-214926
AAV-h-MAP3K12

Ready-to-use AAV expressing Human MAP3K12 (mitogen-activated protein kinase kinase kinase 12). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DLK; MEKK12; MUK; ZPK; ZPKP1
Description (Vector)
MAP3K12 encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.
Gene ID
7786
Gene Name (Vector)
mitogen-activated protein kinase kinase kinase 12
Gene Symbol
MAP3K12
HGNC ID
HGNC:6851
ORF Size (aa)
1704
ORF Size (bp)
1704 bp
RefSeq ID
NM_006301
RefSeq Synonyms
NM_006301, NM_001193511, BC050050,
Species
human
UniGene ID
Hs.713539

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.