human MAP3K7IP2 Over-expression AAV
This is an AAV expressing Human TAB2.
AAV-214940
AAV-h-MAP3K7IP2
Ready-to-use AAV expressing Human TAB2 (TGF-beta activated kinase 1/MAP3K7 binding protein 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CHTD2; MAP3K7IP2; mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAB-2; TAK1-binding protein 2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TGF-beta-activated kinase 1-binding protein 2
Description (eCommerce)
TAB2 (TGF-beta-activated kinase 1and MAP3K7-binding protein 2) functions as an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. TAB2 forms a kinase complex with TRAF6, MAP3K7 and TAB1, and thus serves as an adaptor linking MAP3K7 and TRAF6. TAB2, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts [taken from NCBI Entrez Gene (GeneID: 23118)].
Description (Vector)
TAB2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.
Gene ID
23118
Gene Name (eCommerce)
TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Gene Name (Vector)
TGF-beta activated kinase 1/MAP3K7 binding protein 2
Gene Symbol
TAB2
HGNC ID
HGNC:17075
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2082
ORF Size (bp)
2082 bp
Protein Name (eCommerce)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
RefSeq ID
NM_015093
RefSeq Synonyms
NM_015093, NM_001292035, NM_001292034, BC035910,
Research Areas
B-cell Receptor Signaling,Cardiac Development,Cardiology,Cardiovascular,Cytokine Signaling,Fc Receptor Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,MAPK Signaling,NF-kB Signaling,RANKL-RANK Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Wnt Signaling,Zinc-finger
Research Areas (Faceted)
cardiovascular,cell_biology,developmental_biology,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
TAB2 (TGF-beta-activated kinase 1and MAP3K7-binding protein 2) functions as an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. TAB2 forms a kinase complex with TRAF6, MAP3K7 and TAB1, and thus serves as an adaptor linking MAP3K7 and TRAF6. TAB2, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts [taken from NCBI Entrez Gene (GeneID: 23118)].
UniGene ID
Hs.269775
UniProt ID (eCommerce)
Q9NYJ8
Recently Viewed Products
Ad-CMV-Luc
Cat No: 1000
Ad-CMV-Akt1 (Myr)
Cat No: 1020
Ad-CMV-Akt1 (dn)
Cat No: 1021
Ad-CMV-Akt1 (wt)
Cat No: 1022
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.