human NFYC Over-expression AAV

Name 
AAV-h-NFYC
Cat No 
AAV-214113
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human NFYC.

AAV-214113
AAV-h-NFYC

Ready-to-use AAV expressing Human NFYC (nuclear transcription factor Y subunit gamma). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CAAT box DNA-binding protein subunit C; CBFC; CBF-C; CCAAT binding factor subunit C; CCAAT transcription binding factor subunit gamma; H1TF2A; HAP5; histone H1 transcription factor large subunit 2A; HSM; NF-YC; nuclear transcription factor Y subunit C; nuclear transcription factor Y subunit gamma; nuclear transcription factor Y, gamma; transactivator HSM-1; transactivator HSM-1/2; transcription factor NF-Y, C subunit
Description (eCommerce)
Nuclear transcription factor Y gamma (NF-YC) is a subunit of the NF-Y heterotrimeric complex composed of NF-YA, NF-YB, and NF-YC. The NF-Y factor binds the CCAAT box with high specificity and affinity, and it is the major CCAAT-binding activator. All 3 subunits are essential for CCAAT binding. NF-Y plays a role in regulating several cell-cycle regulated genes such as CDC2, CDC25A/B/C, cyclin A2, cyclin B1/B2, and E2F1.
Description (Vector)
NFYC encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
4802
Gene Name (eCommerce)
nuclear transcription factor Y subunit gamma
Gene Name (Vector)
nuclear transcription factor Y subunit gamma
Gene Symbol
NFYC
HGNC ID
HGNC:7806
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1008
ORF Size (bp)
1008 bp
Protein Name (eCommerce)
Nuclear transcription factor Y subunit gamma
RefSeq ID
NM_014223
RefSeq Synonyms
NM_014223, NM_001308115, NM_001308114, NM_001142590, NM_001142589, NM_001142588, NM_001142587, BC005003,
Research Areas
Antigen Processing and Presentation,Immunology,Metabolism/Metabolic Process,Protein Folding,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,immunology,metabolism,signal_transduction,transcription_translation
Species
human
Target Sentence
Nuclear transcription factor Y gamma (NF-YC) is a subunit of the NF-Y heterotrimeric complex composed of NF-YA, NF-YB, and NF-YC. The NF-Y factor binds the CCAAT box with high specificity and affinity, and it is the major CCAAT-binding activator. All 3 subunits are essential for CCAAT binding. NF-Y plays a role in regulating several cell-cycle regulated genes such as CDC2, CDC25A/B/C, cyclin A2, cyclin B1/B2, and E2F1.
UniGene ID
Hs.233458
UniProt ID (eCommerce)
Q13952

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.