human LMAN1 Over-expression AAV

Name 
AAV-h-LMAN1
Cat No 
AAV-214006
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human LMAN1.

AAV-214006
AAV-h-LMAN1

Ready-to-use AAV expressing Human LMAN1 (lectin, mannose binding 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
endoplasmic reticulum-golgi intermediate compartment protein 53; ERGIC53; ERGIC-53; ER-Golgi intermediate compartment 53 kDa protein; F5F8D; FMFD1; gp58; intracellular mannose-specific lectin MR60; Lectin mannose-binding 1; MCFD1; MR60; protein ERGIC-53
Description (eCommerce)
Lectin mannose-binding 1 (LMAN1) is a mannose-specific lectin. LMAN1 may recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P49257].
Description (Vector)
LMAN1 is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.
Gene ID
3998
Gene Name (eCommerce)
lectin, mannose binding 1
Gene Name (Vector)
lectin, mannose binding 1
Gene Symbol
LMAN1
HGNC ID
HGNC:6631
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1533
ORF Size (bp)
1533 bp
Protein Name (eCommerce)
Protein ERGIC-53
RefSeq ID
NM_005570
RefSeq Synonyms
NM_005570, BC032330,
Research Areas
Golgi Apparatus,Metabolism/Metabolic Process,Protein Folding,Signal Transduction,Translational Control
Research Areas (Faceted)
cell_biology,metabolism,signal_transduction,transcription_translation
Species
human
Target Sentence
Lectin mannose-binding 1 (LMAN1) is a mannose-specific lectin. LMAN1 may recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P49257].
UniGene ID
Hs.465295
UniProt ID (eCommerce)
P49257

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.