human KDM1 Over-expression AAV

Name 
AAV-h-KDM1
Cat No 
AAV-212832
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human KDM1A.

AAV-212832
AAV-h-KDM1

Ready-to-use AAV expressing Human KDM1A (lysine demethylase 1A). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
amine oxidase (flavin containing) domain 2; AOF2; BHC110; BRAF35-HDAC complex protein BHC110; CPRF; FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; flavin-containing amine oxidase domain-containing protein 2; KDM1; LSD1; lysine (K)-specific demethylase 1A; lysine-specific histone demethylase 1; lysine-specific histone demethylase 1A
Description (eCommerce)
BHC110/LSD1 is a histone demethylase and a component of several histone deacetylase complexes. BHC110/LSD1 is able to specifically catalyze the demethylation of Lys4 of histone H3. As part of histone deacetylase complexes BHC110/LSD1 functions as a corepressor of transcription. BHC110/LSD1 has also been demonstrated to interact with the androgen receptor and stimulate androgen-receptor-dependent transcription.
Description (Vector)
KDM1A encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.
Gene ID
23028
Gene Name (eCommerce)
lysine demethylase 1A
Gene Name (Vector)
lysine demethylase 1A
Gene Symbol
KDM1A
HGNC ID
HGNC:29079
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2631
ORF Size (bp)
2631 bp
Protein Name (eCommerce)
Lysine-specific histone demethylase 1A
RefSeq ID
NM_015013
RefSeq Synonyms
NM_015013, NM_001009999, BC048134, BC040194,
Research Areas
Apoptosis,Chromatin Remodeling,DNA Damage/Repair,Histone Modification,Neurobiology,Neurodevelopment,Notch Signaling,RNA Binding,Signal Transduction,Transcription Factor/Regulator,Transport
Research Areas (Faceted)
cell_biology,developmental_biology,genetics,transcription_translation,neurobiology,signal_transduction
Species
human
Target Sentence
BHC110/LSD1 is a histone demethylase and a component of several histone deacetylase complexes. BHC110/LSD1 is able to specifically catalyze the demethylation of Lys4 of histone H3. As part of histone deacetylase complexes BHC110/LSD1 functions as a corepressor of transcription. BHC110/LSD1 has also been demonstrated to interact with the androgen receptor and stimulate androgen-receptor-dependent transcription.
UniGene ID
Hs.656420
UniProt ID (eCommerce)
O60341

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.