human KCNA1 Over-expression AAV

Name
AAV-h-KCNA1

Cat No
AAV-212649

Availability
4-5 weeks

This is an AAV expressing Human KCNA1.

AAV-212649

AAV-h-KCNA1

Ready-to-use AAV expressing Human KCNA1 (potassium voltage-gated channel subfamily A member 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AEMK; EA1; HBK1; HUK1; KV1.1; MBK1; MK1; RBK1

Description (Vector)

KCNA1 encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK).

Gene ID

3736

Gene Name (Vector)

potassium voltage-gated channel subfamily A member 1

Gene Symbol

KCNA1

HGNC ID

HGNC:6218

ORF Size (aa)

1488

ORF Size (bp)

1488 bp

RefSeq ID

NM_000217

RefSeq Synonyms

NM_000217, BC112180, BC101733,

Species

human

UniGene ID

Hs.416139

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.