human ITSN1 Over-expression AAV

Name 
AAV-h-ITSN1
Cat No 
AAV-212557
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human ITSN1.

AAV-212557
AAV-h-ITSN1

Ready-to-use AAV expressing Human ITSN1 (intersectin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
human intersectin-SH3 domain-containing protein SH3P17; intersectin 1 (SH3 domain protein); intersectin 1 short form variant 3; intersectin 1 short form variant, 11; intersectin short variant 12; intersectin-1; ITSN; SH3 domain-containing protein 1A; SH3D1A; SH3P17; Src homology 3 domain-containing protein
Description (eCommerce)
Intersectin 1 is an adapter protein that may provide an indirect link between the endocytic membrane traffic and the actin assembly machinery. Intersectin 1 may regulate the formation of clathrin-coated vesicles. Isoform 1 could be involved in brain-specific synaptic vesicle recycling [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q15811].
Description (Vector)
ITSN1 is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far.
Gene ID
6453
Gene Name (eCommerce)
intersectin 1
Gene Name (Vector)
intersectin 1
Gene Symbol
ITSN1
HGNC ID
HGNC:6183
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5151
ORF Size (bp)
5151 bp
Protein Name (eCommerce)
Intersectin-1
RefSeq ID
NM_003024
RefSeq Synonyms
NM_003024, NM_001331012, NM_001331011, NM_001331010, NM_001331009, NM_001331008, NM_001001132, BC117560, BC116186, BC116185,
Research Areas
Apoptosis,GPCR Signaling,Neurobiology,Neurodevelopment,NGF Signaling,Rho Signaling,Signal Transduction,Synapse
Research Areas (Faceted)
signal_transduction,cell_biology,neurobiology,developmental_biology,signal_transduction,neurobiology
Species
human
Target Sentence
Intersectin 1 is an adapter protein that may provide an indirect link between the endocytic membrane traffic and the actin assembly machinery. Intersectin 1 may regulate the formation of clathrin-coated vesicles. Isoform 1 could be involved in brain-specific synaptic vesicle recycling [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q15811].
UniGene ID
Hs.160324
UniProt ID (eCommerce)
Q15811

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.