human ITK Over-expression AAV

Name 
AAV-h-ITK
Cat No 
AAV-212530
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human ITK.

AAV-212530
AAV-h-ITK

Ready-to-use AAV expressing Human ITK (IL2 inducible T-cell kinase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
EMT; homolog of mouse T-cell itk/tsk; IL-2-inducible T-cell kinase; interleukin-2-inducible T-cell kinase; kinase EMT; LPFS1; LYK; PSCTK2; T-cell-specific kinase; tyrosine-protein kinase ITK/TSK; tyrosine-protein kinase LYK
Description (eCommerce)
Interleukin-2-inducible T-cell kinase (ITK) is an intracellular tyrosine kinase expressed in T-cells. ITK contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation [taken from NCBI Entrez Gene (Gene ID: 3702)].
Description (Vector)
ITK encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.
Gene ID
3702
Gene Name (eCommerce)
IL2 inducible T cell kinase
Gene Name (Vector)
IL2 inducible T-cell kinase
Gene Symbol
ITK
HGNC ID
HGNC:6171
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1863
ORF Size (bp)
1863 bp
Protein Name (eCommerce)
Tyrosine-protein kinase ITK/TSK
RefSeq ID
NM_005546
RefSeq Synonyms
NM_005546, BC109078, BC109077,
Research Areas
B-cell Receptor Signaling,EPO Signaling,Fc Receptor Signaling,Immunology,Innate Immunity,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,NF-kB Signaling,Signal Transduction,T-cell Receptor Signaling,VEGF Signaling,Zinc-finger
Research Areas (Faceted)
cell_biology,immunology,signal_transduction
Species
human
Target Sentence
Interleukin-2-inducible T-cell kinase (ITK) is an intracellular tyrosine kinase expressed in T-cells. ITK contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation [taken from NCBI Entrez Gene (Gene ID: 3702)].
UniGene ID
Hs.558348
UniProt ID (eCommerce)
Q08881

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.