human IRF3 Over-expression AAV

Name 
AAV-h-IRF3
Cat No 
AAV-212406
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human IRF3.

AAV-212406
AAV-h-IRF3

Ready-to-use AAV expressing Human IRF3 (interferon regulatory factor 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
IIAE7; interferon regulatory factor 3; IRF-3
Description (eCommerce)
Interferon regulatory factor 3 (IRF3) is a member of the IRF family of transcription factors that plays a critical role in immune cell function and development. IRF3 mediates interferon-stimulated response element (ISRE) promoter activation and functions as a molecular switch for antiviral activity.
Description (Vector)
IRF3 encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
3661
Gene Name (eCommerce)
interferon regulatory factor 3
Gene Name (Vector)
interferon regulatory factor 3
Gene Symbol
IRF3
HGNC ID
HGNC:6118
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1359
ORF Size (bp)
1359 bp
Protein Name (eCommerce)
Interferon regulatory factor 3
RefSeq ID
NM_001571
RefSeq Synonyms
NM_001571, NM_001197128, NM_001197127, NM_001197126, NM_001197125, NM_001197124, NM_001197123, NM_001197122, BC071721, BC009395, BC000660,
Research Areas
Cancer,Cytokine Signaling,DNA Damage/Repair,Host-Virus Interactions,IFN Signaling,Immunology,Innate Immunity,NF-kB Signaling,Response to Virus,Toll-like Receptor Signaling,Transcription Factor/Regulator,Viral Carcinogenesis
Research Areas (Faceted)
cancer,cell_biology,genetics,immunology,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
Interferon regulatory factor 3 (IRF3) is a member of the IRF family of transcription factors that plays a critical role in immune cell function and development. IRF3 mediates interferon-stimulated response element (ISRE) promoter activation and functions as a molecular switch for antiviral activity.
UniGene ID
Hs.75254
UniProt ID (eCommerce)
Q14653

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.