human IPO5 Over-expression AAV
This is an AAV expressing Human IPO5.
AAV-212347
AAV-h-IPO5
Ready-to-use AAV expressing Human IPO5 (importin 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
IMB3; imp5; KPNB3; Pse1; RANBP5
Description (Vector)
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.
Gene ID
3843
Gene Name (Vector)
importin 5
Gene Symbol
IPO5
HGNC ID
HGNC:6402
ORF Size (aa)
3348
ORF Size (bp)
3348 bp
RefSeq ID
NM_002271
RefSeq Synonyms
NM_002271, BC045640, BC001497,
Species
human
UniGene ID
Hs.712598
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.