human INPP5E Over-expression AAV

Name 
AAV-h-INPP5E
Cat No 
AAV-212293
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human INPP5E.

AAV-212293
AAV-h-INPP5E

Ready-to-use AAV expressing Human INPP5E (inositol polyphosphate-5-phosphatase E). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CORS1; CPD4; JBTS1; MORMS; pharbin; PPI5PIV
Description (Vector)
INPP5E is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.
Gene ID
56623
Gene Name (Vector)
inositol polyphosphate-5-phosphatase E
Gene Symbol
INPP5E
HGNC ID
HGNC:21474
ORF Size (aa)
1935
ORF Size (bp)
1935 bp
RefSeq ID
NM_019892
RefSeq Synonyms
NM_019892, NM_001318502, BC028032,
Species
human
UniGene ID
Hs.120998

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.