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human INPP5E shRNA silencing AAV

Name 
AAV-h-INPP5E-shRNA
Cat No 
shAAV-212293
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human INPP5E.

shAAV-212293
AAV-h-INPP5E-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human INPP5E (inositol polyphosphate-5-phosphatase E). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CORS1; CPD4; JBTS1; MORMS; pharbin; PPI5PIV
Description (Vector)
INPP5E is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.
Gene ID
56623
Gene Name (Vector)
inositol polyphosphate-5-phosphatase E
Gene Symbol
INPP5E
HGNC ID
HGNC:21474
ORF Size (aa)
1935
ORF Size (bp)
1935 bp
RefSeq ID
NM_019892
RefSeq Synonyms
NM_019892, NM_001318502, BC028032,
Species
human
UniGene ID
Hs.120998

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.