human IMPDH2 Over-expression AAV

Name 
AAV-h-IMPDH2
Cat No 
AAV-212246
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human IMPDH2.

AAV-212246
AAV-h-IMPDH2

Ready-to-use AAV expressing Human IMPDH2 (inosine monophosphate dehydrogenase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
IMPD2; IMPDH-II
Description (Vector)
IMPDH2 encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. IMPDH2 is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
Gene ID
3615
Gene Name (Vector)
inosine monophosphate dehydrogenase 2
Gene Symbol
IMPDH2
HGNC ID
HGNC:6053
ORF Size (aa)
1545
ORF Size (bp)
1545 bp
RefSeq ID
NM_000884
RefSeq Synonyms
NM_000884, BC015567, BC012840, BC006124,
Species
human
UniGene ID
Hs.654400

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.