human IL2RA Over-expression AAV
This is an AAV expressing Human IL2RA.
AAV-212173
AAV-h-IL2RA
Ready-to-use AAV expressing Human IL2RA (interleukin 2 receptor subunit alpha). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD antigen CD25; CD25; IDDM10; IL-2 receptor subunit alpha; IL2R; IL-2R subunit alpha; IL-2-RA; IL2-RA; IMD41; interleukin 2 receptor, alpha; interleukin-2 receptor subunit alpha; p55; TAC antigen; TCGFR
Description (eCommerce)
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. The IL2 receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. [taken from NCBI Entrez Gene (Gene ID: 3559)].
Description (Vector)
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
Gene ID
3559
Gene Name (eCommerce)
interleukin 2 receptor subunit alpha
Gene Name (Vector)
interleukin 2 receptor subunit alpha
Gene Symbol
IL2RA
HGNC ID
HGNC:6008
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
819
Protein Name (eCommerce)
Interleukin-2 receptor subunit alpha
RefSeq ID
NM_000417
RefSeq Synonyms
NM_001308243, NM_001308242, NM_000417, BC156627, BC152889,
Research Areas
Apoptosis,Cytokine Signaling,Host-Virus Interactions,Immunology,Interleukin Signaling,JAK-STAT Signaling,Notch Signaling,PI3K/Akt Signaling,Signal Transduction,T-cell Receptor Signaling,TSLP Signaling
Research Areas (Faceted)
cell_biology,developmental_biology,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. The IL2 receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. [taken from NCBI Entrez Gene (Gene ID: 3559)].
UniGene ID
Hs.231367
UniProt ID (eCommerce)
P01589
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.