human IL2 Over-expression AAV
This is an AAV expressing Human IL2.
AAV-212119
AAV-h-IL2
Ready-to-use AAV expressing Human IL2 (interleukin 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
aldesleukin;IL-2;interleukin-2;involved in regulation of T-cell clonal expansion;lymphokine;T cell growth factor;T-cell growth factor;TCGF
Description (eCommerce)
IL2 is a member of the interleukin cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. IL2 is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The IL2 receptor is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. [taken from NCBI Entrez Gene (Gene ID: 3558)].
Description (Vector)
IL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
Gene ID
3558
Gene Name (eCommerce)
interleukin 2
Gene Name (Vector)
interleukin 2
Gene Symbol
IL2
HGNC ID
HGNC:6001
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
462
Protein Name (eCommerce)
Interleukin-2
RefSeq ID
NM_000586
RefSeq Synonyms
NM_000586, BC070338, BC066257, BC066256, BC066255, BC066254,
Research Areas
Apoptosis,Cancer,Cardiology,Cardiovascular,Cytokine Signaling,Host-Virus Interactions,Immunology,Interleukin Signaling,JAK-STAT Signaling,Neurobiology,PI3K/Akt Signaling,Signal Transduction,T Cell Receptor Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
IL2 is a member of the interleukin cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. IL2 is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The IL2 receptor is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. [taken from NCBI Entrez Gene (Gene ID: 3558)].
UniGene ID
Hs.89679
UniProt ID (eCommerce)
P60568
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.