human IL2 Over-expression AAV

Name 
AAV-h-IL2
Cat No 
AAV-212119
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human IL2.

AAV-212119
AAV-h-IL2

Ready-to-use AAV expressing Human IL2 (interleukin 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
aldesleukin;IL-2;interleukin-2;involved in regulation of T-cell clonal expansion;lymphokine;T cell growth factor;T-cell growth factor;TCGF
Description (eCommerce)
IL2 is a member of the interleukin cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. IL2 is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The IL2 receptor is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. [taken from NCBI Entrez Gene (Gene ID: 3558)].
Description (Vector)
IL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
Gene ID
3558
Gene Name (eCommerce)
interleukin 2
Gene Name (Vector)
interleukin 2
Gene Symbol
IL2
HGNC ID
HGNC:6001
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
462
Protein Name (eCommerce)
Interleukin-2
RefSeq ID
NM_000586
RefSeq Synonyms
NM_000586, BC070338, BC066257, BC066256, BC066255, BC066254,
Research Areas
Apoptosis,Cancer,Cardiology,Cardiovascular,Cytokine Signaling,Host-Virus Interactions,Immunology,Interleukin Signaling,JAK-STAT Signaling,Neurobiology,PI3K/Akt Signaling,Signal Transduction,T Cell Receptor Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
IL2 is a member of the interleukin cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. IL2 is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The IL2 receptor is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. [taken from NCBI Entrez Gene (Gene ID: 3558)].
UniGene ID
Hs.89679
UniProt ID (eCommerce)
P60568

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.