human IL1B Over-expression AAV

Name 
AAV-h-IL1B
Cat No 
AAV-212090
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human IL1B.

AAV-212090
AAV-h-IL1B

Ready-to-use AAV expressing Human IL1B (interleukin 1 beta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
IL-1; IL1-BETA; IL1F2
Description (Vector)
IL1B is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Gene ID
3553
Gene Name (Vector)
interleukin 1 beta
Gene Symbol
IL1B
HGNC ID
HGNC:5992
ORF Size (aa)
810
ORF Size (bp)
810 bp
RefSeq ID
NM_000576
RefSeq Synonyms
NM_000576, BC008678,
Species
human
UniGene ID
Hs.126256

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.