human IL13 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-212040
Availability:
3-5 weeks
Name:
AAV-h-IL13
This is an AAV expressing Human IL13.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- IL13
- Gene Name
- interleukin 13
- Gene ID
- 3596
- Gene Synonyms
- IL-13; P600
- ORF Size
- 246 bp
- RefSeq#
- BC096138
- Gene Description
- IL13 encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
- UniGene ID
- Hs.845
- HGNC ID
- HGNC:5973
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